DDQ TUE 2020-09-01 @ 12:45 PM
5. Design of Experiments¶
5.1. Agenda¶
General Announcements
Term Project: Milestone 0: IRB Training
Discussion
5.2. Introduction¶
Ronald Fisher’s Principles for Designed Experiments
Comparison: Comparisons between treatments are often compared against a scientific control or traditional treatment that acts as baseline.
Randomization: The process of assigning individuals at random to groups or to different groups in an experiment, so that there is a uniform probability of study participation among individuals in the target population.
mitigates confounding
Statistical Replication: Measurements are repeated and full experiments are replicated to help identify the sources of variation.
Blocking: Blocking is the non-random arrangement of experimental units into groups consisting of units that are similar to one another.
Orthogonality: Ideally, dependent variables in an experiment are uncorrelated.
Factorial Design: Instead of testing each discrete dependent variable one at a time, groups are formed so that all combinations of discrete dependent variables (and their levels, if appropriate) are tested.